The Real Reasons Doctors Don’t Check Antibody Levels in Hypothyroid Patients

Logic dictates that if the most common cause of hypothyroidism is from an autoimmune mechanism, then the first test ran on all newly diagnosed hypothyroid patients would be a thyroid antibody test. Well logic doesn’t always reign supreme and in many cases Hashimoto’s Autoimmune thyroid patients go undiagnosed and just given the standard thyroid replacement treatment. I am going to explore the most likely reasons this occurs.

The first and foremost reason most thyroid patients will never have their antibody levels checked is because the treatment protocol does not change based on the mechanism. Most doctors are going to give you synthetic thyroid replacement hormones, intermittently check your TSH, and call it a day. If you continue to suffer with the same symptoms as before they will be attributed to some other ailment, usually depression or anxiety, and be treated accordingly.

The second reason for the failure to order antibody tests, is a branch off of the first reason. Since the treatment is not going to be dictated based off the antibody results (although it should), then running the test becomes “medical waste” in the eyes of the insurance companies. The payment for a test that will not alter the course of treatment is in a way wasteful, but the real waste is in ignoring the underlying cause of the problem and leaving the patient to suffer. Many times patients are mocked and scorned for suggesting a test or treatment that is a bit outside of the tight little box Hashimoto’s patients are placed in.

Having no alternative treatment plan for Autoimmune thyroid, and the resultant medical waste of a test ordered but that has no bearing on the patients treatment are the two main reasons many Hashimoto’s patients go undiagnosed and ignored in the system.

Determining that hypothyroidism is from an immune mechanism, IS important, and should absolutely be managed in more comprehensive way, not only including some type of replacement hormone, but it should also include management of the immune systems destruction of the gland itself. A more comprehensive approach gives the patient a better chance to feel and function normally.

BCL2 Antibody – Inducing Apoptosis

Bcl2 antibody – The Bcl2 gene plays an important role in a large assortment of cellular activities, in particular the regulation of cell death. This is facilitated by including or repressing apoptosis based on environmental stimuli.

Bcl2 plays an important role in the regulation of cell death, either inducing or repressing apoptosis based on environmental effects. Consequently, because of the apoptotic regulation, Bcl2 plays an important role in cancer research, cancer diagnostics and regulation of immune cells. BCL2 gene damage has been identified as a cause of a number of cancers, including melanoma, breast cancer, prostate cancer, lung cancer and certain types of leukemia.

A damaged BCL2 gene is also the cause of resistance to a number of cancer treatments. Therefore, Bcl2 antibody can be used in immunohistochemistry to distinguish cells that contain the target Bcl2 antigen. The antibodies usually react inside healthy tissues with B cells in the mantle zone, in addition to some T cells. In cancer tissues there is a substantial increase in the number of positive cells in follicular lymphoma and several other forms of cancer. On occasions, the presence or absence of Bcl2 staining in biopsies could perhaps be vital for the patient’s prognosis or the probability of a relapse.

The primary function of Bcl2 is to induce apoptosis; it does so by inducing the release of cytochrome c to begin the apoptotic cascade. Therefore, malfunctions in whichever of the Bcl2 gene or in the apoptotic cascade may possibly lead to damaged cells by missing the signal to shut down. Cancer possibly occurs as the result of an imbalance between cell death and cell growth. Anti-apoptotic protein expression and under expression of pro-apoptotic genes can, and often do, result in the lack of cell death that is characteristic of cancer. Apoptosis is very important in immune system regulation, destroying immune cells that recognize self-antigen, possibly aiding in the prevention of harmful autoimmune diseases such as Lupus and Type 1 diabetes.

The Bcl2 antibody can be used in IHC-P (immunohistochemistry) to distinguish cells that contain the target Bcl2 antigen. The antibodies usually react inside healthy tissues with B cells in the mantle zone, in addition to some T cells. Conversely, in cancer tissues there is a substantial increase in the number of positive cells in follicular lymphoma and several other forms of cancer. On occasions, the presence or absence of Bcl2 staining in biopsies could perhaps be vital for the patient’s prognosis or the probability of a relapse.

In a trial experiment the expression of Bcl2 antibody in skeletal muscles could potentially play a role on surviving muscle fibers. As the control muscles was generally positive in the nuclear membrane and cytoplasm in type 2B fibers. This experiment was conducted by using 178 biopsied human pathologic muscles and 10 control muscles by the ABC process.

The antibody can be tested on a range of applications, for instance WB (western blot), IHC-P (immunohistochemistry), and P-ELISA. This is used to test the antibody on a large assortment of model species such as mouse, rat, cow, dog, chicken, pig, and Human.

Prostate Cancer Antibody – Promising Treatment For Your Cancer

A number of researchers have revealed an antibody which will bond with prostate cancer tissue and instigate direct cell death while injected into mice. The discovery would nearly be a treatment to cancer of prostate if outcomes carry over to humans.

It is one of the principal diseases frightening men nowadays. The cancer is #2 on the listing of most widespread cancers in men. More than the past 150 years lots of various treatments have been developed as part of research for prostate cancer treatment.

The study published in PNAS {the Proceedings of the National Academy of Science} stated that the antibody, called F77, was discovered to bond more readily with tissues and cells of cancerous prostate than with benign tissue and cells, and to help the death of cancerous tissue.

Even so, the study showed that it did not be intended for normal tissue or tumor tissues in other areas of the body including the colon, kidney, pancreas, skin cervix, lung, or bladder.

Researchers wrote the antibody “proves promising potential for diagnosis and treatment of the cancer, particularly for androgen-independent metastatic prostate cancer,” which frequently extends to the bones and is not easy to treat.

Antibodies are also already being employed to deal with diseases like lymphoma and breast cancer. It is said that until now there has been no successful antibody therapy for cancer of prostate. However, any research team has produced an antibody named F77 which looks so potential. In spite of the research being at a very early step, it brings up the hope of an effectual treatment for advanced prostate cancer.

Overcome Infertility – Treating Anti-Sperm Antibody in Conventional Perspective

As we mentioned in previous article, conventional medicine plays an important role and most of the time is the first treatment for a couple who for what ever reason cam not conceive after 1 year of unprotected sexual intercourse or can not carry the pregnancy to full term. With the advance of medical technology, conventional medicine has proven record in treating infertility but with some side effects. In this article, we will discuss Laparotomy microsurgery: definition, effects, side effects and risk of conventional medication in treating hormone imbalance.

1. Definition
Antisperm antibody can be produced by either partner. It is defined as a certain class of protein attaches themselves to the sperm, causing other cells in the immune system to attack them, leading to low quality sperm in men and effecting the ability of sperm to fertilize the egg in women.

2. Causes
Since the protein can attach to the sperm, it inhibits the sperm function in egg fertilization
a) Blood contamination
A Man may produce antisperm antibody, if he injures to his testicle or due to surgery such as undescent testicle surgery, testicle biopsy, testicle torsion, etc.
b) Break down of the test barrier
Normally sperm are kept separate from blood and immune system. If there are damage to the barrier for what ever reason, the immune system may recognize the sperm as the foreign intrusion and destroy them.
c) When it is formed
For what ever reasons, antisperm antibody can be formed due to infection, inflammation or medicine, etc. If it exist, it may interferes with quality of sperm in men and make cervical mucus hostile to sperm invasion, leading to infertility.

3. Treatments
a) Corticosteroids
Corticosteroids is a drug which normally used to treat any swelling condition such as skin problems, severe allergies, asthma, and arthritis. It works effectively in reducing the production of antisperm antibody, but it causes serious side effect including make infections harder to treat, nervousness, restlessness, sleep problems, and indigestion.
b) Sperm treatments that use for ertificila insemination such as rapid washing and freeze-thawing.